HK97 capsid maturation protease
![HK97 assembly showing protease action](img/PIproteasePacman.png)
Tailed bacteriophages and herpesviruses build their capsids by co-assembling their major capsid protein
with an internal scaffolding protein that is removed from the prohead intact or in pieces after
it is digested by a maturation protease. Phage HK97's scaffolding protein is the 102 residue N-terminal
delta domain of the major capsid protein which is also removed by proteolysis after assembly by
a protease, which we have characterized. The protease has N-terminal cleavage and C-terminal packaging domains.
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Functional domains of the HK97 capsid maturation protease and the mechanisms of protein encapsidation.
- Duda, R. L., B. Oh, and R. W. Hendrix.
- 2013. J Mol Biol 425:2765-81.
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