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Satish Singh

1178A Benedum Hall

Department of Chemical and Petroleum Egineering

University of Pittsburgh, Pittsburgh

PA 15261

Email: sss42@pitt.edu

Phone: 412 624 3376 (office)


Calcium phosphate cements (CPCs) are known to be biodegradable and osteoconductive. Generally, CPCs consist of either Brushite (dicalcium phosphate dihydrate, DCPD) or hydroxyapatite (HA) as their final setting product. Although brushite is acidic and has poor mechanical characteristics, it resorbs in vivo at a much faster rate compared to HA. There is a great demand to engineer bone cement compositions in such a way that the cement should not only be neutral, but also resorbs at a rate which matches very closely to the natural in vivo bone regeneration rate. In this respect biphasic cement consisting of DCPD and HA can be a very promising candidate. In the present work pure HA and silicate-, carbonate- or silicate-carbonate-doped HA (ASHA) was synthesized.  These doped or undoped HA were reacted giving biphasic cements consisting of mixtures of HA and DCPD. Carbonate substituted HA is the major inorganic component of the natural bone and silicon is an essential trace element for bone growth and regeneration. The effect of varying the amount of substitutions of silicate and carbonate on the kinetics of cement setting, and evaluation of different crystalline phases under in vitro conditions and their influences on cell proliferation are being.