| Department of Environmental and Occupational Health |
Patricia Opresko - Research
Research Interests
Molecular mechanisms of genomic instability associated with cancer and aging, with an initial focus on telomeric DNA
- Genetic and environmental factors that alter rates of telomere attrition
- Mechanism of telomere loss in the progeroid disorder Werner syndrome. Roles of the Werner syndrome protein in repair and replication of telomeric DNA
- Cellular pathways that repair and restore damaged telomeric DNA
Confocal images of illustrating the effects of chromium (Cr VI) on proliferation
of EYFP-WRN U2OS cells. Liu and colleagues demonstrate the role of the
Werner Syndrome protein in repairing Cr (VI)-induced DNA damage
Lab Photos
