Pitt Logo

dept. of structural biology



Solid State NMR

Protein & Amyloid

Protein-Lipid Interaction

SSNMR Methods




Selected Links

Contact info

web site hit




Search  entrez Entrez Pubmed or see below. Please feel free to contact me for reprints or if you have any comments and/or questions!


Targeted 13C-13C Distance Measurements in a Microcrystalline Protein via J-Decoupled Rotational Resonance Width Measurements.
Van der Wel, P.C.A.; Eddy, M.T.; Ramachandran, R., and Griffin, R.G. (2009) ChemPhysChem 10 (9-10): 1656-1663 

High-Resolution Solid-State NMR Structure of Alanyl-Prolyl-Glycine.
Barnes, A.B.; Andreas, L.; Huber, M.; Ramachandran, R.; van der Wel, P.C.A.; Veshtort, M.; Griffin, R.G., and Griffin, R.G. (2009) J. Mag. Res. 200 (1), 95-100

Cryogenic sample exchange NMR probe for magic angle spinning dynamic nuclear polarization
Barnes, A.B.; Mak-Jurkauskas, M.L.; Matsuki, Y.; Bajaj, V.S.; van der Wel, P.C.A.; DeRocher, R.; Bryant, J.; Sirigiri, J.R.; Temkin, R.J.; Lugtenburg, J.; Herzfeld, J., and Griffin, R.G. (2009) J. Mag. Res. 198 (2): 261-270

Observation of a low-temperature, dynamically driven structural transition in a polypeptide by solid state NMR spectroscopy
Bajaj, V.S.; van der Wel, P.C.A., and Griffin, R.G. (2009) J. Am. Chem. Soc. 131(1): 118128 


High field dynamic nuclear polarization for solid and solution biological NMR (review article)
Barnes, A.B.; De Pape, G.; van der Wel, P.C.A.; Hu, K.-N.; Joo, C.-G.; Bajaj, V.S.; Mak-Jurkauskas, M.L.; Sirigiri, J.R.; Herzfeld, J.; Temkin, R.J., and Griffin, R.G. (2008) Appl. Magn. Reson. 34(3-4): 237-263 Online  DOI 

Dynamic nuclear polarization at high magnetic fields (review article)
Maly, T.; Debelouchina, G.T.; Bajaj, V.S.; Hu, K.-N.; Joo, C.-G.; Mak-Jurkauskas, M.L.; Sirigiri, J.R.; van der Wel, P.C.A.; Herzfeld, J.; Temkin, R.J., and Griffin, R.G. (2008) J. Chem. Phys. 128(1): 052211  Online DOI

Helical distortion in tryptophan and lysine anchored membrane-spanning alpha helices as a function of hydrophobic mismatch: A solid-state deuterium NMR investigation using the GALA method
Daily, A.E.; Greathouse, D.V.; van der Wel, P.C.A., and Koeppe, R.E., II (2008) Biophys. J. 94: 480-491 Online DOI


Solid state NMR study of amyloid nanocrystals and fibrils formed by the peptide GNNQQNY from yeast prion protein Sup35p.
Van der Wel, P.C.A.; Lewandowski, J.R., and Griffin, R.G. (2007) J. Am. Chem. Soc. 129(16): 5117-5130 Online DOI

Orientation and motion of tryptophan interfacial anchors in membrane-spanning peptides.
Van der Wel, P.C.A.; Reed, N.D.; Greathouse, D.V., and Koeppe, R.E., II (2007) Biochemistry 46(25):7514-24  Abstract DOI PMC PDF


 Dynamic nuclear polarization of amyloidogenic peptide nanocrystals: GNNQQNY, a core segment of the yeast prion protein Sup35p.
Van der Wel, P.C.A.; Hu, K.-N.; Lewandowski, J.R., and Griffin, R.G. (2006) J. Am. Chem. Soc. 128(33):10840-10846 Abstract DOI

Multipole-multimode Floquet theory of rotational resonance width experiments: 13C-13C distance measurements in uniformly labeled solids.
Ramachandran, R.; Lewandowski, J.R.; van der Wel, P.C.A., and Griffin, R.G. (2006) J. Chem. Phys. 124(21): 214107 Abstract


Importance of tensor asymmetry for the analysis of 2H-NMR spectra from deuterated aromatic rings.
Pulay, P.; Scherer, E.M.; van der Wel, P.C.A., and Koeppe, R.E. II (2005) J. Am. Chem. Soc. 127(49): 17488-93. Abstract DOI  PMC PDF 


Complexes obtained by electrophilic attack on a dinitrogen-derived terminal molybdenum nitride: electronic structure analysis by solid state CP/MAS 15N NMR in combination with DFT calculations.
Sceats, E.L.; Figueroa, J.S.; Cummins, C.C.; Loening, N.M.; van der Wel, P.C.A., and Griffin, R.G. (2004) Polyhedron 23: 2751-2768  Abstract DOI

Tilt angles of transmembrane model peptides in oriented and nonoriented lipid bilayers as determined by 2H solid-state NMR.
Strandberg, E.; Ozdirekcan, S.; Rijkers, D.T.; van der Wel, P.C.A.; Koeppe, R.E. II; Liskamp, R.M., and Killian, J.A. (2004) Biophys J.  86: 3709-3721 Abstract   DOI   PMC PDF


Combined experimental/theoretical refinement of indole ring geometry using deuterium magnetic resonance and ab initio calculations.
Koeppe, R.E., II; Sun, H.; van der Wel, P.C.A.; Scherer, E.M.; Pulay, P., and Greathouse, D.V. (2003) J. Am. Chem. Soc. 125: 12268-12276. Abstract DOI

Hydrophobic mismatch between helices and lipid bilayers.
Weiss, T.M.; van der Wel, P.C.A.; Killian, J.A.; Koeppe, R.E., II, and Huang, H.W. (2003) Biophys J. 84: 379-385 Abstract  PMC PDF


Geometry and intrinsic tilt of a tryptophan anchored membrane spanning peptide by 2H NMR.
Van der Wel, P.C.A.; Strandberg, E.; Killian, J.A., and Koeppe, R.E., II (2002) Biophys. J. 83(3): 1479-1488 Abstract Full Text  Info PMC PDF

Lipid dependence of membrane anchoring properties and snorkeling behaviour of aromatic and charged residues in transmembrane peptides.
Strandberg, E.; Morein, S.; Rijkers, D.T.S.; Liskamp, R.M.J.; van der Wel, P.C.A., and Killian, J.A. (2002) Biochemistry 41(23): 7190-7198 Abstract PubMed

Optimized aminolysis conditions for cleavage of N-protected hydrophobic peptides from solid-phase resins.
Greathouse, D.V.; Goforth, R.L.; Crawford, T.; van der Wel, P.C.A., and Killian, J.A. (2001) J. Peptide Res. 57: 519-527. Abstract PubMed


Tryptophan-anchored transmembrane peptides promote formation of nonlamellar phases in phosphatidylethanolamine model membranes in a mismatch-dependent manner.
Van der Wel, P.C.A.; Pott, T.; Morein, S.; Greathouse, D.V.; Koeppe II, R.E., and Killian, J.A.  (2000) Biochemistry 39: 3124-33. Abstract Info PDF DOI


Peptide influences on lipids.
Killian, J.A.; Morein, S.; van der Wel, P.C.A.; de Planque, M.R.R.; Greathouse, D.V., and Koeppe, R.E., II. (1999) Novartis Found Symp. 225: 170-83; discussion 183-7. Abstract

Modulation of membrane structure and function by hydrophobic mismatch between proteins and lipids
Killian, J.A.; de Planque, M.R.R.; van der Wel, P.C.A.; Salemink, I.; de Kruijff, B.; Greathouse, D.V., and Koeppe, R.E., II (1998) Pure & Appl. Chem. 70: 75-82. PDF