Time-Dependent Interaction between Synaptic Potentiation and Depression




Munro Paul

Department of Information Science and Telecommunications

School of Information Sciences

University of Pittsburgh

E1440 BST

135 North Bellefield Avenue

Pittsburgh, PA 15260


phone: +1 (412) 624-9427

fax: +1 (412) 624-2778

e-mail: pmunro@mail.sis.pitt.edu









The dependence of synaptic plasticity on neural activity is a key concept in understanding the biological basis of learning, memory, and even perhaps cognition itself. In the decades since Hebb's articulation of his neurophysiological hypothesis, neuroscientists have progressed through many stages of theoretical and experimental development. Along the way, a mathematical "rule" for activity-dependent plasticity was put forward by Bienestock, Cooper, and Munro (1982) that accounts for the development of selective response properties in cortical neurons. Here, I will present an overview of the rule from the perspective of dynamical systems.