Sant Lab

Developing Biomimetic Microenvironments for Regenerative Therapies

Department of Pharmaceutical Sciences, University of Pittsburgh, PA




26. Nanomaterials in Tissue Engineering: Fabrication and applications, Woodhead Publisher, Gaharwar, AK., Sant, S., Hacking, SA, Hancock, M. eds  (August 2013).


25. Sant, S., Coutinho, D., Sadr, N., Khademhosseini, A. Tissue-analogs by assembly of engineered hydrogel blocks In: Biomimetic approaches for biomaterial development, Joao F. Mano ed., Wiley-VCH, Verlag,GmBH.

24.  Rabanel, J-M, Bertrand, B., Sant, S., Louati, S. and Hildgen, P., Polysaccharide hydrogels for the preparation of immunoisolated cell delivery systems In: Polysaccharides for drug delivery and pharmaceutical applications, Robert H. Marchessault, Francois Ravenelle And Xiao Xia Zhu Eds., American Chemical Society, Washington, ACS Symposium series no. 934, 2006, pp. 305-339.

Journal Articles


23. Goenka, S. Sant, V., Sant, S.*, Graphene-based nanomaterials for drug delivery and tissue engineering, J Control Rel 2014 173:75.



22. Gaharwar AK, Mihaila SM, Swami A, Patel A, Sant S, Reis RL, Marques AP, Gomes ME*, Khademhosseini, A*, Bioactive Silicate Nanoplatelets for Osteogenic Differentiation of Human Mesenchymal Stem Cells, Adv Mater 2013 25 (24): 3329.

21. Sant, S., Iyer, D., Gaharwar, A., Khademhosseini, A., Effect of biodegradation and de novo matrix synthesis on the mechanical properties of valvular interstitial cell-seeded polyglycerol sebacate-polycaprolactone scaffolds,  Acta Biomaterialia, 2013 9 (4):5963.



20. Bae, H., Chu, H., Edalat, F., Cha, J. M., Sant, S., Kashyap, A., Ahari, A., Kwon, C. H., Nichol, J. W., Manoucheri, S., Wang, Y., Khademhosseini, A., Development of functional biomaterials with micro- and nanoscale technologies for tissue engineering and drug delivery applications, J Tissue Eng Regen Med, doi: 10.1002/term.1494.

19. Coutinho, D.*, Sant, S.*, Shakiba, M., Wang, B., Gomes, ME, Neves, NM, Reis, RL, Khademhosseini, A., Microfabricated photocrosslinkable polyelectrolyte-complex of chitosan and methacrylated gellan gum, J Mater Chem, 2012 22: 17262.

18. Sant, S., Tao, S., Fisher, O., Xu, Q., Khademhosseini, A., Microfabrication technologies for oral drug delivery, Adv Drug Deliv Rev, 2012 64(6): 496.



17. Tong, Z.; Sant, S.; Khademhosseini A.; and Jia, X. Fibroblastic differentiation of human mesenchymal stem cells cultured on fibrous polyester scaffolds, Tissue Engineering Part A, 2011 17(21-22): 2773.

16. Kwon CH, Wheeldon I, Kachouie N, Lee SH, Bae H, Sant, S., Fukuda, J., Kang JW, Khademhosseini A, Drug eluting microarrays for cell-based screening of chemical-induced apoptosis, Analytical Chemistry, 2011 83(11):4118.

15. Yamanlar, S.*, Sant, S.*, Picart, C., Khademhosseini, A., Surface functionalization of hyaluronic acid hydrogels by polyelectrolyte multilayer films, Biomaterials, 2011 32(24):5590 Highlighted in Extracellular Matrix Cell News, 2.19 in the issue of 19th May 2011.

14. Sant, S., Hwang, CM, Lee, S-H., Khademhosseini, A., Hybrid PGS-PCL Microfibrous scaffolds with improved mechanical and biological properties, J Tissue Eng Regen Med, 2011 5:283.

13. Soliman, S., Sant, S.,  Nichol, J. W., Khabiry, M., Travesa, E. and Khademhosseini, A., Controlling porosity of fibrous scaffolds by modulating packing density and fiber diameter, J Biomed Mater Res A, 2011 96A(3):566.

12. Mahmoudi, M., Sant, S., Wang, B., Laurent, S., Sen, T., Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy, Adv Drug Deliv Rev, 2011 63:24-46, One of the top hottest articles (2010) and Topmost 3rd article in Sciencedirect (2011).



11. Sant, S., Hancock, MJ, Donnelly, JP, Iyer, D., Khademhosseini, A., Biomimetic gradient hydrogels for tissue Engineering, Can J Chem Eng, 2010 88(6): 899 One of the top ten most-accessed articles (2010).

10. Sant, S. and Khademhosseini, A., Fabrication and characterization of tough elastomeric fibrous scaffolds for tissue engineering applications, Conf Proc IEEE Eng Med Biol Soc. 2010;1:354.

9. Coutinho, D., Sant, S., Shin, H., Oliveira, JT, Gomes, ME, Neves, NM, Khademhosseini, A., Reis, RL Modified Gellan Gum Hydrogels with Tunable Mechanical and Degradation properties; Biomaterials, 2010 31(29):7494.

8. Hwang, CM, Sant, S., Masaeli, M., Zamanian, B., Lee, S-H., Khademhosseini, A., Fabrication of 3D porous cell-laden hydrogel Scaffolds, Biofabrication, 2010, 2: 1.



7. Sant, S., Poulin, S. and Hildgen P., Effect of polymer chemistry of pegylated nanoparticles on their surface properties, plasma protein adsorption and cellular interactions, J Biomed Mater Res A, 2008 87(4):885.

6. Sant, S., Thommes, M. and Hildgen P., Microporous structure and drug release kinetics of polymeric nanoparticles, Langmuir, 2008, 24 (1): 280.



5. Nadeau V., Rabanel J-M, Sant, S., Chahwan, R., Clas, S-D., and Hildgen, P., Synthesis and characterization of biodegradable and charged salen-based polymers, J. Appl. Polymer Sci, 2006, 102 (3): 2568.



4. Sant, S., Nadeau, V. and Hildgen P., Effect of porosity on the release kinetics of propafenone-loaded PEG-g-PLA nanoparticles, J Control Release, 2005, 107(2): 203.

3. Nadeau, V., Leclair, G., Sant, S., Rabanel J-M., Quesnel R., and Hildgen P., Synthesis of new versatile functionalized polyesters for biomedical applications, Polymer, 2005, 46(25): 11263.



2. Gaikwad, SY, Jagtap, AG, Ingle, AD, Rao, SGA and Gude, RP., Antimetastatic activity of niosomal pentoxifylline and its combination with activated macrophages in murine B16F10 melanoma model, Cancer Biotherapy and Radiopharmaceuticals, 2000, 15 (6), 605.

1. Jagtap, AG and Gaikwad SY, Applications of genomic pharmacology in cancer treatment, (Review) Indian Drugs, 2000, 37 (1), 22.


1.      Faculty of Pharmacy, University of Montreal, 1 Nov 2013, Canada Invited speaker.

2.     Mechanics and Engineering of Cellular Systems, Biomechanics Day, Carnegie Mellon University, September 2013, Invited speaker.

3.      The Center for Craniofacial Regeneration, University of Pittsburgh, April 2013, USA, Invited speaker.

4.      Gaharwar A.K.*, Nikkah M.*, Sant S.*, Patel A., Silvia SM, Khademhosseini A., Effect of PGS-PCL electrospun fibers orientation on alignment and proliferation of Human Umbilical Vein Endothelial Cells, Society for Biomaterials, April 2013, Boston, MA, USA, Selected for Merit Award by SFB.

5.      3rd annual meeting, CMBE-BMES, Jan 2013, Hawaii, USA, Rising Star/Fellow Award.

6.     CU Shah College of Pharmacy, SNDT University, December 2012, Mumbai, India, Invited speaker.

7.    IIT Bombay, December 2012, Mumbai, India, Invited speaker.

8.      Vivekanand Education Society's College of Pharmacy, Mumbai University, December 2012, Mumbai, India, Invited speaker.

9.  BIND12, December 2012, Banaglore, India, Contributory Invited speaker.

10.  IIT Madras, December 2012, Chennai, India, Invited speaker.

11. Central Leather Research Institute, December 2012, Chennai, India, Invited speaker.

12.  Li, C-C*, Sant S*, Ravisankar A., Khademhosseini A., Maas RL, In vitro manipulation of BMP4 gradient in early odontogenesis, HKSDB, November 2012 Hong Kong.

13.  Sant S., Postdoctoral Fellowships: Challenges and Opportunities, National Institute of Biomedical Imaging and Bioengineering, NIH, June 2012, Bethesda, MD, USA Invited speaker.

14.  University of Pittsburgh, School of Pharmacy, Jan 2012, PA, USA Invited speaker.

15.  Faculty of Pharmacy, University of Manitoba, Jan 2012, Winnipeg, Canada Invited speaker.

16.  Coutinho D.F., Sant S., Gomes M.E., Neves N.M., Reis R.L., Khademhosseini A. Natural-based photocrosslinkable polyelectrolyte complex hydrogel: development and microfabrication. XXXVIII Congress of the European Society for Artificial Organs (ESAO 2011) and IV Biennial Congress of the International Federation on Artificial Organs (IFAO 2011), October 2011, Porto, Portugal.

17.  Coutinho D.F., Sant S., Gomes M.E., Neves N.M., Reis R.L., Khademhosseini A. Three-dimensional hydrogel mimics hierarchy and size of natural fiber bundles, XXXVIII Congress of the European Society for Artificial Organs (ESAO 2011) and IV Biennial Congress of the International Federation on Artificial Organs (IFAO 2011), October 2011, Porto, Portugal.

18.  Coutinho D.F., Sant S., Shakiba M., Gomes M.E., Neves N.M., Reis R.L., Khademhosseini A.. Fabrication of Hydrogel Fiber Bundles from Assembly of Polyelectrolytes, European Chapter of the Tissue Engineering and Regenerative Medicine International Society (EU-TERMIS), June 2011, Spain.

19.  Coutinho D.F., Sant S., Shakiba M., Wang B., Gomes M.E., Neves N.M., Reis R.L., Khademhosseini A.. Photocrosslinkable polyelectrolyte complex hydrogel with potential for tissue-engineering at micron scale. 9th International Symposium on Frontiers in Biomedical Polymers, May 2011, Madeira, Portugal.

20.  University of New Mexico, May 2011, USA Invited speaker.

21.  Sant S., Wheeldon I., Iyer D., Calpe B., Bick A., Khademhosseini A., Biomaterial engineering for heart valve design, System-based Consortium for Organ Design and Engineering (SysCODE) retreat, April 2011, Waltham, MA Invited speaker.

22.  Sant S., Coutinho D., Yamanlar S., Wang B., Khademhosseini A., Engineering Biomaterials to Modulate Drug Release and cellular Interaction, SysCODE, December 2010, Boston, MA, Invited speaker.

23.  Yamanlar S.*, Sant S.*, Picart C., Khademhosseini, A., Surface functionalization of hydrogels by polyelectrolyte multilayer films for tissue engineering, Biomedical Engineering Society, October 2010, USA.

24.  Khademhosseini A and Sant S.., Fabrication and Characterization of Tough Elastomeric Fibrous Scaffolds for Tissue Engineering Applications, 32nd Annual International IEEE EMBS Conference, September 2010, Argentina.

25.  Sant, S. and Khademhosseini, A., MMP-sensitive hydrogel system to study dental epithelial-mesenchymal  interaction, SysCODE, Tooth Regeneration Project, July 2010, Boston, MA.

26.  Sant S., Hwang CM, Lee SH and Khademhosseini A., Mechanical and biological evaluation of poly(glycerol sebacate) microfibrous scaffolds, Society for Biomaterials, April 2010, Recipient of STAR Award, ** Honorable Mention for Best Research Abstract**

27.  Department of Pharmaceutical Sciences, Washington State University, November 2009, Pullman, WA Invited speaker.

28.  Sant S., Engineering Biomaterials to modulate drug release and cellular interaction, Topics in Bioengineering, Harvard School of Engineering and Applied Sciences, November 2009, Boston, MA Invited speaker.

29.  Bayoumi A, Sant S., Hwang CM, Khademhosseini A., Mayer J., Heart valve design and engineering, SysCODE Retreat, October 2009, Boston, MA.

30.  Sant S., Optimization of composite PGS-PCL scaffolds for tissue engineering applications, SysCODE, June 2009, Boston, MA.

31.  Sant S. and Hildgen P., Polymeric nanoparticles of doxorubicin for circumventing multidrug resistance, In "Biological Challenges session"; 33rd International Symposium on Controlled Release of Bioactive Materials, Vienna, Austria, July 2006, Recipient of Travel Grant.