Histology
Stanley Shostak
BioSc
1450
Spring 05
Lecture 9. Hematopoiesis
self-renewing vs. transient: determinism vs.
differentiation (mitotic and non-mitotic)
Cells : all formed in bone marrow
(h[a]ematopoiesis)
divisional (mitosis) in bone marrow:
pluripotential hematopoietic stem
cell (small population: set aside stem cells)
self renewing pluripotent stem cell
burst or -blast (blast forming unit: BFU)
(proerythroblast; lymphoblast; myeloblast;
monocytoblast, megakaryoblast)
mitotic but not self renewing
transient stem cell = colony forming unit
(CFU)
bipotential stem cell: composite
granulocyte-monocyte [GM] colony forming unit
unipotent stem cell: basophilic erythroblast
=
early normoblast; promyelocyte, promonocyte
post-divisional erythrocyte line
erythrocyte line: normoblast
Intermediate normoblast = polychromatophilic
erythroblast
Late normoblast = orthochromatic erythroblast
reticulocyte
post-divisional myelocyte (monocyte) line
metamyelocyte
stab cell (band cell)
definitive myelocytes and monocytes
megakaryoblasts > megakaryocytes >
fragmentation of platelets and regeneration
last revised: 02-01-05