The following recommendations are meant to provide general guidance for decisions related to treatment of children with HIV infection, and flexibility should be exercised according to the child�s individual circumstances. Guidelines for when to start antiretroviral therapy and the choice of drug regimens are evolving. Treatment with HAART has had a dramatic impact on the health of children with HIV infection. However, attainment of these benefits requires rigorous adherence to demanding treatment schedules.
Additionally, therapy is associated with short- and long-term toxicities, some of which are only now beginning to be appreciated in children [78, 79]. Whenever possible, decisions regarding the management of pediatric HIV infection should be directed by, or in consultation with, a specialist in pediatric and adolescent HIV infection.