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Case History 

In the summer of 1991, just after my 37th birthday, I began feeling an unshakable fatigue and a persistent pain in my left side.
Like most people, I had had episodes of hypochondria -- could that headache be a brain tumor? -- but I had always been in generally robust health

By October, I was worried enough to see my physician for a long-overdue physical.
"You seem fine," he told me, "but let's do some blood tests just to be sure."