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�144
SNPs identified in 93 cases and 93 controls, excluded 96 from further
analysis due to low MAF or complete correlation with other SNPs
�48
SNPs chose for genotyping, only one in coding region (exon 2) and was
synonymous
�Several
haplotypes were significantly associated with the disease at an adjusted
significance level of
P
< 0.05 (Supplementary
Table 5 online). We observed the most significant association with a
four-SNP haplotype spanning 33 kb, including the first four exons of
ALOX5AP
(Fig. 1c), with a nominal
P
value of 0.0000023 and an adjusted
P
value of 0.005. This haplotype, called HapA, has a haplotype frequency
of 15.8% (carrier frequency 29.1%) in affected individuals versus 9.5%
(carrier frequency 18.1%) in controls (Table 1).
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