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These
pictures are of airway lumens of the mice. Picture A is from a sedentary
mouse and B is from an exercised mouse, both mice had been experimentally
induced with an asthmatic state. Notice the difference in airway diameter
between the exercised and sedentary mice. The graph represents the
differences in inflammatory parameters including: 1) perivascular and
peribronchial lymphoid accumulations (*remember that the lymphoid tissues
contain lymphocytes- they were measuring leukocyte infiltration). 2)
hypertrophy (increase in size)& hyperplasia (which is an increase in number
of cells) of the mucosal epithelium; 3) goblet cell and mucin production
and(Goblet
cells
are glandular
simple columnar
epithelial
cells
whose sole function is to secrete
mucus &
Mucins which
are a family of large, heavily glycosylated
proteins
which are increased in asthmatics) 4) overall index of inflammation. Notice
that the dark lines represent the exercised group which scored lower in all
inflammatory parameters! This was my favorite study! Now if we could just
reproduce this with some asthmatic school aged children- kiddingJ
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