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Outside the niche, stem cells differentiate because the absence of signals lead to differentiation, stem cells hard to propagate what are the signals how is range controled
•the
intrinsic state of the cell (stem-ness)
•outside
signals
•Self-renewing
signals: very complex
1. inhibit differentiation 2. control proliferation 3. are local and niches have a limited capacity 4. include the main developmental pathways: Notch, Hedgehog, BMP, FGF and Wnt
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