hs-CRP and risk of future MI in apparently healthy men

In the prospective Physicians' Health Study, a cohort of almost 22,000 healthy, middle-aged men were tracked over an 8- to 10-year period for first ever occurrence of myocardial infarction (MI).  As shown in the slide, the relative risk of a future MI increases in a direct linear fashion as the level of hs-CRP goes from low-normal to high-normal.  This effect was highly statistically significant, and in fact, hs-CRP was as strong a predictor in this cohort as was cholesterol level.  It is important to point that these data were derived from a high-sensitivity CRP assay; that is, all the levels of inflammation detected here are well within normal limits; none of these individuals have chronic inflammatory disorders.

Reference:

Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997;336:973-979.

http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9077376&dopt=Abstract

Keywords:  C-reactive protein, Physicians' Health Study

Slide type:  graph