Wei Chen

Wei Chen

Professor of Pediatrics

University of Pittsburgh

Principal Investigator

My lab focuses on developing statistical and computational methods for the analysis of large-scale biomedical data and applying them to study complex diseases. Collaborating with our colleagues, we use cutting-edge technologies including DNA-seq, RNA-seq, methylation, ATAC-seq and single cell sequencing to study human diseases such as childhood asthma and age-related macular degeneration. Chen lab welcomes collaborators and trainees to move science forward. Our lab is generously supported by National Institute of Health, National Science Foundation, University of Pittsburgh and UPMC.

Recent News

  • 3/2022 Wei Chen was appointed as Adjunct Professor of Biomedical Engineering (BME) at Carnegie Mellon University
  • 3/2022 Molin Yue and Zhongli Xu received ATS Abstract scholarship
  • 2/2022 Xinjun Wang accepted the faculty position (Assistant Attending Biostatistician) at Memorial Sloan Kettering Cancer Center
  • 1/2022 Molin Yue’s 2 abstracts were accepted for oral presentation at 2022 ATS International Conference
  • 7/2021 Wei Chen was promoted to full professor

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Recent Publications

  • Yan Q, Forno E, C Celedón J, Chen W. A region-based method for causal mediation analysis of DNA methylation data. Epigenetics. 2022 Mar;17(3):286-296.

  • Yan Q, Ding Y, Weeks DE, Chen W. AMD Genetics: Methods and Analyses for Association, Progression, and Prediction. Adv Exp Med Biol. 2021;1256:191-200.

  • Xin H, Lian Q, Jiang Y, Luo J, Wang X, Erb C, Xu Z, Zhang X, Heidrich-O’Hare E, Yan Q, Duerr RH, Chen K, Chen W. GMM-Demux: sample demultiplexing, multiplet detection, experiment planning, and novel cell-type verification in single cell sequencing. Genome Biol. 2020 Jul 30;21(1):188.

  • Wang X, Sun Z, Zhang Y, Xu Z, Xin H, Huang H, Duerr RH, Chen K, Ding Y, Chen W. BREM-SC: a bayesian random effects mixture model for joint clustering single cell multi-omics data. Nucleic Acids Res. 2020 Jun 19;48(11):5814-5824.

  • Kim S, Forno E, Yan Q, Jiang Y, Zhang R, Boutaoui N, Acosta-Pérez E, Canino G, Chen W, Celedón JC. SNPs identified by GWAS affect asthma risk through DNA methylation and expression of cis-genes in airway epithelium. Eur Respir J. 2020 Apr;55(4).

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