Converting from PLINK format to PANGAEA MORGAN format with Mega2

The free Mega2 software can convert from PLINK format to PANGAEA MORGAN format, as well as to a number of other formats.

During an association or linkage analysis project, it can often be quite difficult to get one's data in the proper format desired by each different computer program. Not only must the data be transformed to the proper format, but also the loci must be reordered into their proper order. To address this problem, we created Mega2, which can be obtained from our software distribution site.

Mega2 greatly eases and automates the tedious error-prone process of reformatting one's data from one format to another.

For additional information, please see the Mega2 documentation.

Input: PLINK format

For further information about PLINK, see:

Mega2 Input documentation: PLINK
PLINK documentation
Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81(3):559–575. doi: 10.1086/519795. PMID: 17701901. PMC1950838.

Output: PANGAEA MORGAN format

For further information about PANGAEA MORGAN format, see:

Mega2 Analysis documentation: PANGAEA MORGAN format
MORGAN
Thompson EA. (1994) Monte Carlo likelihood in the genetic mapping of complex traits. Philos Trans R Soc Lond B Biol Sci 344(1310):345–350; discussion 350–341. doi: 10.1098/rstb.1994.0073.
Thompson EA. (1994) Monte Carlo likelihood in genetic mapping. Statistical Science 9(3):355–366. doi: 10.1214/ss/1177010381.

Mega2 documentation

Documentation for Mega2 is available here in both HTML and PDF format.

Downloading Mega2

Mega2 can be obtained from our software distribution site.

Pre-compiled executables are available for Linux, Macintosh, Solaris, and Windows (native, Cygwin, MinGW).

Citing Mega2

If you use Mega2 as part of a published work, please remember to reference Mega2. You may reference it by citing the following:

Baron RV, Kollar C, Mukhopadhyay N, Weeks DE
Mega2: validated data-reformatting for linkage and association analyses
Source Code for Biology and Medicine. 2014, 9:26
DOI: 10.1186/s13029-014-0026-y

as well as citing the web site and the version that you used. For example, the web site citation for version 4.9.1 should be:

Baron RV, Kollar CP, Mukhopadhyay N, Almasy L, Schroeder M, Mulvihill WP, Weeks DE (2015) Mega2 (Version 4.9.1). https://watson.hgen.pitt.edu

Support, bug reports, and feedback

Mega2 Google Group

Mega2 users are invited to participate in our Mega2 Google Group at https://groups.google.com/forum/#!forum/mega2-users. Support questions should be posted there.

Bug reports

If you encounter a bug in Mega2, please send us a detailed bug report, including the following information:

Program Name: Mega2
Program Version: [Mega2 prints out a version number when you first start it up.]
Platform: [Windows, Macintosh, Linux, etc.]
Description:
Example files: [If you can, please send us example files that will allow us to try to re-create the bug on our own computers.]

Please send your bug reports and feedback to: Daniel E. Weeks at weeks@pitt.edu

Contact information

Daniel E. Weeks, Ph.D. Professor of Human Genetics and Biostatistics
Department of Human Genetics
Graduate School of Public Health
University of Pittsburgh
Crabtree Hall, Room A303
130 DeSoto Street
Pittsburgh, PA 15261
USA

1 412 624-5388
FAX: 1 412 624-3020
E-mail: weeks@pitt.edu
Web page: https://watson.hgen.pitt.edu

Grant Acknowledgments

Mega2 is currently supported by the University of Pittsburgh and the following NIH grant: R01GM076667 (Weeks, Daniel E).
Prior work on Mega2 was partly supported by R01AG16989 (D.E.W.), R01HG00932 (D.E.W.), and R01AG16992 (to Jeffrey R. O'Connell).
In addition, parts of Mega2 were inspired by data generated under NIH grant R01DK55406 to Ranjan Deka.