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C. SUBROUTINE LIBRARIES


C.1. Frequency: papfq

C.1.1. papfqa2

	Genotype Assignments:	Autosomal
	Number of Loci:	2
	Number of Alleles:	2 at first locus, unrestricted at second locus
	Assumptions:		Hardy-
Weinberg equilibrium
	Parameters:		Conditional allele frequencies first locus
				Allele frequencies at second locus

C.1.2. papfqa2s

	Genotype Assignments:	Category-specific autosomal
	Number of Loci:	2
	Number of Alleles:	2 at first locus, unrestricted at second locus
	Assumptions:	Hardy-
Weinberg equilibrium
	Parameters:	Conditional allele frequencies first locus
		Allele frequencies at second locus

C.1.3. papfqg

	Genotype Assignments:	No restrictions
	Number of Loci:	No restrictions
	Number of Alleles:	No restrictions
	Assumptions:	None
	Parameters:	Genotype frequencies

C.1.4. papfqh

	Genotype Assignments:	Autosomal
	Number of Loci:	2+
	Number of Alleles:	No restrictions
	Assumptions:	Hardy-
Weinberg equilibrium
	Parameters:	Haplotype frequencies

C.1.5. papfqh2

	Genotype Assignments:	Autosomal
	Number of Loci:	2
	Number of Alleles:	2 at each locus
	Assumptions:	Hardy-
Weinberg equilibrium
	Parameters:	Allele frequencies
D (disequilibrium)

C.1.6. papfqhw

	Genotype Assignments:	Not Autosomal/X-linked mixed
	Number of Loci:	No restrictions
	Number of Alleles:	No restrictions
	Assumptions:	Hardy-
Weinberg equilibrium
Linkage equilibrium
	Parameters:	Allele frequencies

C.1.7. papfqx2

	Genotype Assignments:	X-linked
	Number of Loci:	2
	Number of Alleles:	2 at each
	Assumptions:	Hardy-
Weinberg equilibrium
	Parameters:	Allele frequencies
		D (disequilibrium)

C.1.8. papfqxa [Hasstedt & Skolnick 1984]

	Genotype Assignments:	Autosomal/X-linked mixed
	Number of Loci:	1
	Number of Alleles:	2
	Assumptions:	Hardy-
Weinberg equilibrium in female
Generational equilibrium in males
	Parameters:	Allele frequencies

C.2. Transmission: paptc

C.2.1. paptcal

	Genotype Assignments:	Autosomal
	Number of Loci:	2+
	Number of Alleles:	No restrictions
	Assumptions:	Mendelian segregation
	Parameters:	Sex-specific recombination probabilities

C.2.2. paptcapl

	Genotype Assignments:	Parent-specific autosomal
	Number of Loci:	2+
	Number of Alleles:	No restrictions
	Assumptions:	Mendelian segregation
	Parameters:	Sex-specific recombination probabilities

C.2.3. paptcasl

	Genotype Assignments:	Category-specific autosomal
	Number of Loci:	2+
	Number of Alleles:	No restrictions
	Assumptions:	Mendelian segregation
	Parameters:	Sex-specific recombination probabilities

C.2.4. paptcaxl

	Genotype Assignments:	Autosomal/X-linked admixture
	Number of Loci:	2+
	Number of Alleles:	No restrictions
	Assumptions:	Mendelian segregation
	Parameters:	Sex-specific recombination probabilities

C.2.5. paptce

	Genotype Assignments:	No restrictions
	Number of Loci:	No restrictions
	Number of Alleles:	No restrictions
	Assumptions:	Transmission probabilities equal genotype frequencies
	Parameters:	None

C.2.6. paptcet

	Genotype Assignments:	Not autosomal/X-linked mixed model
	Number of Loci:	1
	Number of Alleles:	2
	Assumptions:	Generational equilibrium
	Parameters:	Allele transmission probabilities

C.2.7. paptcms

	Genotype Assignments:	No restrictions
	Number of Loci:	No restrictions
	Number of Alleles:	No restrictions
	Assumptions:	Mendelian segregation
		Unlinked loci
	Parameters:	None

C.2.8. paptctp

	Genotype Assignments:	Not autosomal/X-linked mixed
	Number of Loci:	1
	Number of Alleles:	2
	Assumptions:	None
	Parameters:	Allele transmission probabilities

C.2.9. paptcxl

	Genotype Assignments:	X-linked
	Number of Loci:	2+
	Number of Alleles:	No restrictions
	Assumptions:	Mendelian segregation
	Parameters:	Female recombination probabilities

C.2.10 paptcxpl

	Genotype Assignments:	Parent-specific X-linked
	Number of Loci:	2+
	Number of Alleles:	No restrictions
	Assumptions:	Mendelian segregation
	Parameters:	Sex-specific recombination probabilities

C.3. Major Locus Discrete: dmlpr

C.3.1. dmlprin

	Number of Loci:	1
	Number of Alleles:	2
	Mode of Inheritance:	Autosomal
	Population Data:	Incidence rates
	Phenotype:	Disease dichotomy
	Assumptions:	Earlier onset corresponds to higher liability
	Parameters:	Dominance
Displacement in within-genotype standard deviations

C.3.2. dmlprpn

	Number of Loci:	Unrestricted
	Number of Alleles:	Unrestricted
	Mode of Inheritance:	Unrestricted
	Population Data:	None
	Phenotype:	Disease dichotomy
	Assumptions:	None
	Parameters:	Penetrance for each genotype

C.3.3. dmlprpr

	Number of Loci:	1
	Number of Alleles:	2
	Mode of Inheritance:	Autosomal
	Population Data:	Prevalence rates
	Phenotype:	Disease dichotomy
	Assumptions:	Earlier onset corresponds to higher liability
	Parameters:	Dominance
Displacement in within-genotype standard deviations

C.3.4. dmlprsv

	Number of Loci:	1
	Number of Alleles:	2
	Mode of Inheritance:	Autosomal
	Population Data:	Prevalence by disease severity
	Phenotype:	Severity code
	Assumptions:	Penetrance increases across the genotypes
	Parameters:	Dominance
Displacement in within-genotype standard deviations

C.4. Major Locus Quantitative: qmlpr

C.4.1. qmlprdd

	Number of Loci:	1
	Number of Alleles:	2
	Mode of Inheritance:	Autosomal
	Population Data:	None
	Assumptions:	Equal variance within genotypes
	Parameters:	Total mean
Total standard deviation
Dominance
Displacement in within-genotype standard deviations
Power for transformation
Coefficients of linear effects (0-5)

C.4.2. qmlprmv

	Number of Loci:	Unrestricted
	Number of Alleles:	Unrestricted
	Mode of Inheritance:	Unrestricted
	Population Data:	None
	Assumptions:	None
	Parameters:	Mean for each genotype
Standard deviation for each genotype
Power for transformation
Coefficients of linear effects (0-5)

C.4.3. qmlprmvt

	Number of Loci:	Unrestricted
	Number of Alleles:	Unrestricted
	Mode of Inheritance:	Unrestricted
	Population Data:	None
	Assumptions:	Affection corresponds to a value above a specified threshold
	Parameters:	Mean for each genotype
Standard deviation for each genotype
Threshold
Power for transformation
Coefficients of linear effects (0-5)

C.5. Within Genotype: papwg

C.5.1. papwgam [Hasstedt 1995]

	Assumptions:	Within-genotype correlations modeled as variance components
		Assortative mating
	Parameters:	Assortative mating correlation
		Polygenic heritability
Variance components for shared environments
Genetic correlation between traits
Environmental correlation between traits
C.5.2. papwgfc
	Assumptions:	Within-genotype correlation modeled as familial correlations
Familial correlations zero outside nuclear family
	Parameters:	Spouse correlation
Parent-offspring correlation
Sibling correlation
Correlation between traits

C.5.3. papwgml

	Assumptions:	No within-genotype correlations
	Parameters:	Correlation between traits

C.5.4. papwgvc [Hasstedt 1993]

	Assumptions:	Within-genotype correlations modeled as variance components
	Parameters:	Polygenic heritability
Variance components for shared environments
Genetic correlation between traits
Environmental correlation between traits


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