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Aaron Barchowsky - Publications

Refereed Articles - past 5 years

    1. Straub, AC, DB Stolz , MA Ross, A Hernandez, V Soucy, LR Klei, and A Barchowsky. Arsenic stimulates sinusoidal endothelial cell capillarization and vessel remodeling in mouse liver. Hepatology 45:205-212, 2007. PMID: 17187425

    2. O'Hara, KO, RJ Vaghjiani, AA Nemec, LR Klei, and A Barchowsky. Chromium(VI)-stimulated STAT3 tyrosine phosphorylation and nuclear translocation in human airway epithelial cells requires Lck. Biochem J. 402:261-269, 2007. PMID: 17078813

    3. Straub, AC, DB Stolz, H. Vin, MA Ross, NV Soucy, LR Klei, and A Barchowsky. Low level arsenic promotes progressive inflammatory angiogenesis and liver blood vessel remodeling in mice. Toxicol. Appl. Pharmacol. 222:327-336, 2007 PMID: 17123562

    4. Shenberger JS, L Zhang, RJ Powell, and A Barchowsky.  Hyperoxia enhances VEGF release from A549 cells via post-transcriptional processes. Free Radic Biol Med. 43:844-852, 2007. PMID: 17664148

    5. Zhao, J, RW Harper, A Barchowsky, YP Di. Identification of multiple MAPK-mediated transcription factors regulated by tobacco smoke in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 293:L480-l490, 2007. PMID: 17496060

    6. Shvedova, A.A., Fabisiak, J.P., Kisin, E.R., Murray, A., Roberts, J., Antonini, J., Kommineini, C., Reynolds, J., Barchwosky, A., Castranova, V., and Kagan, V.E. Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity. Am. J. Respir. Cell Molec. Biol., 38: 579-90, 2008. PMID: 18096873

    7. Klei, L R and Barchowsky, A. Positive Signaling Interactions between Arsenic and Ethanol for Angiogenic Gene Induction in Human Microvascular Endothelial Cells. Toxicol Sci. 2008 Apr;102(2):319-27. Epub 2008 Jan 8. PMID: 18182400

    8. Basu P, Ghosh RN, Grove LE, Klei L, Barchowsky A. Angiogenic potential of 3-nitro-4-hydroxy benzene arsonic Acid (roxarsone). Environ Health Perspect. 2008 Apr;116(4):520-3. PMID: 18414637

    9. Dougherty D, Garte S, Barchowsky A, Zmuda J, Taioli E. NQO1, MPO, CYP2E1, GSTT1 and GSTM1 polymorphisms and biological effects of benzene exposure-A literature review.  Toxicol Lett. 2008 Sep 20.  PMID: 18848868

    10. Straub AC, Clark KA, Ross MA, Chandra AG, Li S, Gao X, Pagano PJ, Stolz DB, Barchowsky A.  Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxide.  J Clin Invest. 2008 Nov 13.  PMID: 19009047

    11. States JC, Srivastava S, Chen Y, Barchowsky A. Arsenic and Cardiovascular Disease. Toxicol Sci. 2008 Nov 17. PMID: 19015167

    12. Nemec AA, Leikauf G, Pitt BR, Wasserloos KJ, Barchowsky A.   Nickel Mobilizes Intracellular Zinc to Induce Metallothionein in Human Airway Epithelial Cells.  Am J Respir Cell Mol Biol. 2008 Dec 18.  PMID: 19097988

    13. Bein K, Wesselkamper SC, Liu X, Dietsch M, Majumder N, Concel VJ, Medvedovic M, Sartor M, Henning LN, Venditto C, Borchers MT, Barchowsky A, Weaver TE, Tichelaar JW, Prows DR, Korfhagen TR, Hardie WD, Bachurski CJ, Leikauf GD.  Surfactant Associated Protein B is Critical to Survival in Nickel-induced Injury in Mice.  Am J Respir Cell Mol Biol. 2009 Jan 8. PMID: 19131640

    14. Straub AC, LR Klei, DB Stolz, A Barchowsky.  Arsenic requires sphingosine-1-phosphate type 1 receptors to induce angiogenic genes and endothelial cell remodeling. Am J Pathol 174, May 2009. PMID: 19349368

    15. Nemec AA, Barchowsky A. Signal transducer and activator of transcription 1 (STAT1) is essential for chromium silencing of gene induction in human airway epithelial cells. Toxicol Sci. 2009 Apr 29. PMID: 19403854

    16. Liu FJ, Barchowsky A, Opresko PL. The Werner Syndrome Protein Functions in Repair of Cr (VI)-induced Replication.  Associated DNA Damage. Toxicol Sci. 2009 Jun 1. PMID: 19487340

    17. Nemec AA, LM Zubritsky and A Barchowsky. Chromium(VI) stimulates Fyn to initiate innate immune gene induction in human airway epithelial cells. Chem Res Toxicol 23(2):396-404, 2010 PMID: 19994902

    18. Jang AS, Concel VJ, Bein K, Brant KA, Liu S, Pope-Varsalona H, Dopico Jr. RA, Di YP, Knoell DL, Barchowsky A, Leikauf GD. Endothelial Dysfunction and Claudin 5 Regulation during Acrolein-induced Lung Injury. Am J Respir Cell Mol Biol. 2011 Apr;44(4):483-90. Epub 2010 Jun 4. PubMed PMID: 20525806

    19. Liu FJ, Barchowsky A, Opresko PL. The Werner Syndrome Protein Suppresses Telomeric Instability Caused by Chromium (VI) Induced DNA Replication Stress. PLoS One. 2010 Jun 16;5(6):e11152. PubMed PMID: 20585393

    20. Gao F, Brant KA, Ward R, Cattley RT, Barchowsky A, Fabisiak JP. Multiple Protein Kinase Pathways Mediate Amplified IL-6 Release by Human Lung Fibroblasts Co-Exposed to Nickel and TLR-2 Agonist, MALP-2. Toxicol Appl Pharmacol. 2010 Sep 1;247(2):146-57. Epub 2010 Jun 17. PubMed PMID: 20600219

    21. Barchowsky A, Buckley LA, Carlson GP, Fitsanakis VA, Ford SM, Genter MB, Germolec DR, Leavens TL, Lehman-McKeeman LD, Safe SH, Sulentic CE, Eidemiller BJ. The Toxicology Education Summit: building the future of toxicology through education. Toxicol Sci. 2012 Mar 29. PMID: 22461448

    22. Malek AM, A Barchowsky, R Bowser, A Youk, EO Talbott. Pesticide exposure as a risk factor for amyotrophic lateral sclerosis: A meta-analysis of epidemiological studies. Environ. Res. (2012) http://dx.doi.org/10.1016/j.envres.2012.06.007

Published Abstracts - past 5 years

    1. Nemec, A, A, KA O’Hara, LR Klei, RJ Vaghjiani, A Barchowsky. Chromium(VI) induces genes through STAT1 transactivation of interferon-stimulated response elements.  The Toxicologist  96:224, 2007.

    2. Barchowsky, A., A.C. Straub, DB Stolz.  Arsenic-induced endothelial cell activation and vascular remodeling.  The Toxicologist 96:262, 2007.

    3. Straub, AC, DB Stolz, MA Ross, LR. Klei, A Barchowsky.  Arsenic stimulates hepatic capillarization and increases sinusoidal endothelial membrane bound Rac1-GTPase in vivo and ex vivo. The Toxicologist 96:306, 2007.

    4. Klei, LR and A Barchowsky. Synergies in vascular cell signaling stimulated by co-exposure to arsenic and ethanol.   The Toxicologist 96:306, 2007.

    5. Murray, AR, E Kisin, JP Fabisiak, JR Roberts, JM Antonini, C Kommineni, J Reynolds, A Barchowsky, V Castranova, V Kagan, and AA Shvedova. Combined exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity. The Toxicologist 102:306, 2008.

    6. Nemec, A A, SA Sandel, GD Leikauf, BR Pitt, and A Barchowsky. Nickel induces metallothionein in airway epithelial cells by increasing intracellular zinc.  The Toxicologist 102:330, 2008.

    7. Straub, AC, DB Stolz, KA Clark, AG Chandura, and A Barchowsky.  Arsenic signals through NADPH oxidase to promote mouse liver sinusoidal endothelial cell defenestration and increased PECAM-1 expression.  The Toxicologist 102:333, 2008.

    8. Barchowsky, A, LR Klei, AC Straub, and D B Stolz. Signaling mechanisms for vascular responses to arsenic.  The Toxicologist 102:405, 2008.

    9. Klei, LR and A Barchowsky. Arsenic signals through a Gai-coupled pathway to induce angiogenic genes in human microvascular cells.   The Toxicologist 102:456, 2008.

    10. Nemec, AA and A Barchowsky Chromium silences nickel-induced vascular endothelial growth factor (VEGF) expression in human airway epithelial cells FASEB J. 22:764.3, 2008.

    11. Straub, AC, DB Stolz, KA Clark, and A Barchowsky. Arsenic signals through g-proteins and NADPH Oxidase (NOX) to promote mouse liver sinusoidal endothelial cell capillarization. FASEB J. 22:900.4, 2008.

    12. Klei, LR, AC Straub, DB Stolz, and A Barchowsky.  Arsenic requires sphingosine-1-phosphate type 1 receptors to stimulate vascular remodeling.  The Toxicologist 108: 43, 2009.

    13. Liu, F, A Barchowsky, and PL Opresko.  The Werner syndrome protein functions in repair of Cr(VI)-induced stalled DNA replication forks.  The Toxicologist 108: 220, 2009.

    14. Mann, KK, AM Padovani, WH Miller, AC Straub, and A Barchowsky.  Low dose arsenic potentiates a pro-atherogenic phenotype in macrophages and liver. The Toxicologist 108: 370, 2009.

    15. Nemec, A A and A Barchowsky. STAT1 is essential for chromium silencing of nickel-induced VEGF expression in human airway epithelial cells.  The Toxicologist 108:370, 2009.

    16. Barchowsky, A, LR Klei, AC Straub, DB Stolz.  Arsenic requires sphingosine-1-phosphate type 1 receptors to induce angiogenic genes and endothelial cell remodeling. FASEB J. 23:116.10, 2009.

    17. Barchowsky, A (session chair) Signaling mechanisms for metabolic dysfunction following low-level arsenic exposures: from mouse to man. The Toxicologist 114:122, 2010.

    18. Barchowsky, A, AC Straub, LR Klei, KK Mann, DB Stolz. Arsenic signaling for liver vascular remodeling impacts protein and lipid metabolism. The Toxicologist 114:123, 2010.

    19. Liu, F, A Barchowsky, PA Opresko. Cr(VI) exposure induces telomere loss and defects. The Toxicologist 114:144, 2010.

    20. Liu, F, KE Knickelbein, A Barchowsky and PL Opresko. Mechanisms of the Werner syndrome protein in protecting against Cr(VIV) induced telomere loss. Abstract 121 The Toxicologist CD 120: S-2: 25, 2011.

    21. Klei, LR, Y Garciafigueroa, RT Cattley and A Barchowsky. Arsenic induces metabolic regulators and differentiation in adipose tissue. Abstract 1968 The Toxicologist CD 120: S-2: 421, 2011.

    22. Klei, LR and A Barchowsky. Dysfunctional regulation of metabolic and mitochondrial gene expression following arsenic exposures. Abstract 1438 The Toxicologist 126: 310, 2012.

    23. Ambrosio, F, B. Goodpaster, L. Niedernhofer, B. Van Houten, G.Distefano,E. H. Brown1 and A. Barchowsky. Cellular, metabolic, and histological evidence for arsenic-induced myopathy. Abstract 2069 The Toxicologist 126: 446, 2012.

    24. Barchowsky A, S. H. Safe, C. W. Sulentic, M. Genter and G. Carlson. (session chair)The future of toxicology education: outcomes of the toxicology educational summit. Abstract 2184 The Toxicologist 126: 471, 2012.

Invited Reviews - past 5 years

Prozialeck WC, Edwards JR, Nebert DW, Woods JM, Barchowsky A, Atchison WD. The vascular system as a target of metal toxicity. Toxicol Sci. 2008 Apr; 102 ( 2 ): 207-18 . Epub 2007 Oct 18. PMID: 17947343

States JC, Srivastava S, Chen Y, Barchowsky A. Arsenic and Cardiovascular Disease. Toxicol Sci. 107:312-323, 2009. PMID: 19015167

Mossman, BT, M Lippman, TW Hesterberg, KT Kelsey, A Barchowsky, and JC Bonner. Pulmonary endpoints (lung carcinomas and asbestosis) following inhalation exposure to asbestos. J Toxicol Environ Health B Crit Rev. 14:76-121, 2011. PMID: 21534086

States JC, Barchowsky A, Cartwright IL, Reichard JF, Futscher BW, Lantz RC. Arsenic Toxicology: Translating between Experimental Models and Human Pathology. Environ Health Perspect. 2011 Jun 17. PubMed PMID:21684831

Al Ghouleh I, Khoo NK, Knaus UG, Griendling KK, Touyz RM, Thannickal VJ, Barchowsky A, Nauseef WM, Kelley EE, Bauer PM, Darley-Usmar V, Shiva S, Cifuentes-Pagano E, Freeman BA, Gladwin MT, Pagano PJ. Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling. Free Radic Biol Med. 2011 Jun 14. [Epub ahead of print] PubMed PMID: 21722728

Barchowsky A, LA Buckley, GP Carlson, VA Fitsanakis, SM Ford, MB Genter, DR Germolec, TL Leavens, LD Lehman-McKeeman, SH Safe, CE Sulentic, and BJ Eidemiller.  The toxicology education summit: building the future of toxicology through education.  Toxicol Sci. 127:331-8, 2012.  PMID: 22461448