PUBLICATIONS

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80. T.W. Harmon, Y. Lin, R.T. Sutton, S.W.J. Osborne, W.S. Horne* “Interplay between Cα methylation and Cα stereochemistry in the folding energetics of a helix-rich miniprotein.” ChemBioChem 2025, in press. [DOI]
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79. T.W. Harmon, J. Song, A.J. Gulewicz, Y.P. Di*, W.S. Horne* “Structural and functional mimicry of the antimicrobial defensin plectasin by analogues with engineered backbone composition.” ChemBioChem 2025, in press. [DOI]
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78. J.A. Wolfe, W.S. Horne* “Application of artificial backbone connectivity in the development of metalloenzyme mimics.” Curr. Opin. Chem. Biol. 2024, 81, 102509. [DOI]
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77. Y. Lin, W.S. Horne* “Backbone modification in a protein hydrophobic core.” Chem. Eur. J. 2024, 30, e202401890. [DOI]
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76. S.L. Heath, A.J. Guseman, A.M. Gronenborn*, W.S. Horne* “Probing effects of site-specific aspartic acid isomerization on structure and stability of GB1 through chemical protein synthesis.” Prot. Sci. 2024, 33, e4883. [DOI]
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75. J.R. Santhouse, J.M.G. Leung, L.T. Chong*, W.S. Horne* “Effects of altered backbone composition on the folding kinetics and mechanism of an ultrafast-folding protein.” Chem. Sci. 2024, 15, 675-682. [DOI]
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74. S.L. Heath, W.S. Horne, G.A. Lengyel* “Effects of chirality and side chain length in Cα,α-dialkylated residues on β-hairpin peptide folded structure and stability.” Org. Biomol. Chem. 2023, 21, 6320-6324. [DOI]
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73. T.W. Harmon, W.S. Horne* “Protein backbone alteration in non-hairpin β-turns: Impacts on tertiary folded structure and folded stability.” ChemBioChem 2023, e202300113. [DOI]
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72. S.R. Rao, T.W. Harmon, S.L. Heath, J.A. Wolfe, J.R. Santhouse, G.L. O’Brien, A.N. Distefano, Z.E. Reinert, W.S. Horne* “NMR chemical shifts of artificial monomers used to construct heterogeneous-backbone protein mimetics in random coil and folded states.” Pept. Sci. 2023, 115, e24297. [DOI]
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71. J.R. Santhouse, J.M.G. Leung, L.T. Chong*, W.S. Horne* “Implications of the unfolded state in the folding energetics of heterogeneous-backbone protein mimetics.” Chem. Sci. 2022, 13, 11798-11806. [DOI]
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70. C. Clever, E. Wierzbinski, B. Bloom, Y. Lu, H.M. Grimm, S.R. Rao, W.S. Horne, D.H. Waldeck* “Benchmarking chiral induced spin selectivity measurements: Towards meaningful comparisons of chiral biomolecule spin polarizations.” Isr. J. Chem. 2022, e202200045. [DOI]
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69. C.C. Cabalteja, Q. Lin, T.W. Harmon, S.R. Rao, Y.P. Di*, W.S. Horne* “Heterogeneous-backbone proteomimetic analogues of lasiocepsin, a disulfide-rich antimicrobial peptide with a compact tertiary fold.” ACS Chem. Biol. 2022, 17, 987-997. [DOI]
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68. J.R. Santhouse, S.R. Rao, W.S. Horne* “Analysis of folded structure and folding thermodynamics in heterogeneous-backbone proteomimetics.” Methods Enzymol. 2021, 656, 93-122. [DOI]
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67. C.C. Cabalteja, W.S. Horne* “Application of chemical synthesis to engineer protein backbone connectivity.” In Total Chemical Synthesis of Proteins; A. Brik, P.E. Dawson, L. Liu (Eds.); Wiley-VCH: Weinheim, 2021, 515-532. [link]
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66. S.R. Rao, S.L. Schettler, W.S. Horne* “Metal-binding foldamers.” ChemPlusChem 2021, 86, 137-145. [DOI]
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65. K. Jang, W.S. Horne*, S Asher* “Human serum phenylpyruvate quantification using responsive 2D photonic crystal hydrogels via chemoselective oxime ligation: Progress towards developing phenylalanine-sensing elements.” ACS Appl. Mater. Interfaces 2020, 12, 39612-39619. [DOI]
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64. A.T. Bogetti, H.E. Piston, J.M.G. Leung, C.C. Cabalteja, D.T. Yang, A.J. DeGrave, K.T. Debiec, D.S. Cerutti, D.A. Case, W.S. Horne*, L.T. Chong* “A twist in the road less traveled: The AMBER ff15ipq-m force field for protein mimetics.” J. Chem. Phys. 2020, 153, 064101. [DOI]
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63. S.R. Rao, W.S. Horne* “Proteomimetic zinc finger domains with modified metal‐binding β‐turns.” Pept. Sci. 2020, e24177. [DOI]
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62. W.S. Horne*, T.N. Grossmann* “Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns.” Nature Chem. 2020, 12, 331-337. [DOI]
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61. N.C. Miller, H.M. Grimm, W.S. Horne, G.R. Hutchison* “Accurate electromechanical characterization of soft molecular monolayers using piezo force microscopy.” Nanoscale Adv. 2019, 1, 4834-4843. [DOI]
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60. S. Arora, W.S. Horne, K. Islam* “Engineering methyllysine writers and readers for allele-specific regulation of protein-protein interactions.” J. Am. Chem. Soc. 2019, 141, 15466-15470. [DOI]
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59. K.A. Scheib, N.A. Tavenor, M.J. Lawless, S. Saxena, W.S. Horne* “Understanding and controlling the metal-directed self assembly of terpyridine-functionalized coiled-coil peptides.” Chem. Commun. 2019, 55, 7752-7755. [DOI]
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58. H.M. Werner, S.K. Estabrooks, G.M. Preston, J.L. Brodsky, W.S. Horne* “Exploring the functional consequences of protein backbone alteration in ubiquitin through native chemical ligation.” ChemBioChem 2019, 20, 7752-7755. [DOI]
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57. C.C. Cabalteja, D.S. Mihalko, W.S. Horne* "Heterogeneous-backbone foldamer mimics of a computationally designed, disulfide-rich miniprotein." ChemBioChem 2019, 20, 103-110. [DOI]
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56. K.L. George, W.S. Horne* "Foldamer tertiary structure through sequence-guided protein backbone alteration." Acc. Chem. Res. 2018, 51, 1220-1228. [DOI]
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55. C.W. Marvin, H.M. Grimm, N.C. Miller, W.S. Horne*, G.R. Hutchison* "Interplay among sequence, folding propensity, and bio-piezoelectric response in short peptides and peptoids." J. Phys. Chem. B 2017, 121, 10269-10275. [DOI]
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54. K.L. George, W.S. Horne* "Heterogeneous-backbone foldamer mimics of zinc finger tertiary structure." J. Am. Chem. Soc. 2017, 139, 7931-7938. [DOI]
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53. N.A. Tavenor, M.J. Murnin, W.S. Horne* "Supramolecular metal-coordination polymers, nets, and frameworks from synthetic coiled-coil peptides." J. Am. Chem. Soc. 2017, 139, 2212-2215. [DOI]
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52. M. Matmor, G.A. Lengyel, W.S. Horne*, N. Ashkenasy* "Peptide-functionalized semiconductor surfaces: Strong surface electronic effects from minor alterations to backbone composition." Phys. Chem. Chem. Phys. 2017, 19, 5709-5714. [DOI]
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51. C.R. Walters, D.M. Szantai-Kis, Y. Zhang, Z.E. Reinert, W.S. Horne, D.M. Chenoweth, E.J. Petersson* "The effects of thioamide backbone substitution on protein stability: A study in α-helical, β-sheet, and polyproline II helical contexts." Chem. Sci. 2017, 8, 2868-2877. [DOI]
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50. K. Kar, M.A. Baker, G.A. Lengyel, C.L. Hoop, R. Kodali, I.-J. Byeon, W.S. Horne, P.C.A. van der Wel, R. Wetzel* "Backbone engineering within a latent β-hairpin structure to design inhibitors of polyglutamine amyloid formation." J. Mol. Biol. 2017, 429, 308-323. [DOI]
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49. M.A. Karnes, S.L. Schettler, H.M. Werner, A.F. Kurz, W.S. Horne, G.A. Lengyel* "Thermodynamic and structural impact of α,α-dialkylated residue incorporation in a β-hairpin peptide." Org. Lett. 2016, 18, 3902-3905. [DOI]
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48. C.M. Haney, H.M. Werner, J.J. McKay, W.S. Horne* "Thermodynamic origin of α-helix stabilization by side-chain cross-links in a small protein." Org. Biomol. Chem. 2016, 14, 5768-5773. [DOI]
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47. T.F. Cunningham, S. Pornsuwan, W.S. Horne*, S. Saxena* "Rotameric preferences of a protein spin label at edge-strand β-sheet sites." Prot. Sci. 2016, 24, 1049-1060. [DOI]
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46. N.A. Tavenor, Z.E. Reinert, G.A. Lengyel, B.D. Griffith, W.S. Horne* "Comparison of design strategies for α-helix backbone modification in a protein tertiary fold." Chem. Commun. 2016, 52, 3789-3792. [DOI]
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45. H.M. Werner, C.C. Cabalteja, W.S. Horne* "Peptide backbone composition and proteolytic susceptibility: Impact of modification type, position, and tandem substitution." ChemBioChem 2016, 17, 712-718. [DOI]
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44. W.S. Horne* "Foldamers: Biomimetic and built to order." Nature Chem. 2015, 7, 858-859. [DOI]
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43. H.M. Werner, W.S. Horne* "Folding and function in α/β-peptides: Targets and therapeutic applications." Curr. Opin. Chem. Biol. 2015, 28, 75-82. [DOI]
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42. T.F. Cunningham, M.R. Putterman, A. Desai, W.S. Horne*, S. Saxena* "The double histidine Cu2+-binding motif: A highly rigid, site-specific spin probe for electron spin resonance distance measurements." Angew. Chem. Int. Ed. 2015, 54, 6330-6334. [DOI]
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41. C.M. Haney, W.S. Horne* "Receptor-templated stapling of intrinsically disordered peptide ligands." Org. Biomol. Chem. 2015, 13, 4183-4189. [DOI]
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40. Z.E. Reinert, W.S. Horne* "Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structure." Org. Biomol. Chem. 2014, 12, 8796-8802. [DOI]
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39. N.A. Tavenor, K.I. Silva, S. Saxena*, W.S. Horne* "Origins of structural flexibility in protein-based supramolecular polymers revealed by DEER spectroscopy." J. Phys. Chem. B 2014, 118, 9881-9889. [DOI]
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38. Z.E. Reinert, W.S. Horne* "Folding thermodynamics of protein-like oligomers with heterogeneous backbones." Chem. Sci. 2014, 5, 3325-3330. [DOI]
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37. G.A. Lengyel, Z.E. Reinert, B.D. Griffith, W.S. Horne* "Comparison of backbone modification in protein β-sheets by α->γ residue replacement and α-residue methylation." Org. Biomol. Chem. 2014, 12, 5375-5381. [DOI]
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36. K.M. Oshaben, W.S. Horne* "Tuning assembly size in peptide-based supramolecular polymers by modulation of subunit association affinity." Biomacromolecules 2014, 15, 1436-1442. [DOI]

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35. C.M. Haney, W.S. Horne* "Dynamic covalent side-chain cross links via intermolecular oxime or hydrazone formation from bifunctional peptides and simple organic linkers." J. Pept. Sci. 2014, 20, 108-114. [DOI]
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34. Z.E. Reinert, G.A. Lengyel, W.S. Horne* "Protein-like tertiary folding behavior from heterogeneous backbones." J. Am. Chem. Soc. 2013, 135, 12528-12531. [DOI]

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33. C.M. Haney, W.S. Horne* "Oxime side-chain cross-links in an α-helical coiled-coil protein: Structure, thermodynamics, and folding-templated synthesis of bicyclic species." Chem. Eur. J. 2013, 19, 11342-11351. [DOI]
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32. G.A. Lengyel, G.A. Eddinger, W.S. Horne* "Introduction of cyclically constrained γ-residues stabilizes an α-peptide hairpin in aqueous solution." Org. Lett. 2013, 15, 944-947. [DOI]

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31. K. Kar, C.L. Hoop, K.W. Drombosky, M.A. Baker, R. Kodali, I. Arduini, P.C.A. van der Wel, W.S. Horne, R. Wetzel* "β-Hairpin-mediated nucleation of polyglutamine amyloid formation." J. Mol. Biol. 2013, 425, 1183-1197. [DOI]
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30. K.M. Oshaben, R. Salari, D.R. McCaslin, L.T. Chong*, W.S. Horne* "The native GCN4 leucine-zipper domain does not uniquely specify a dimeric oligomerization state." Biochemistry 2012, 51, 9581-9591. [DOI]
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29. G.A. Lengyel, W.S. Horne* "Design strategies for the sequence-based mimicry of side-chain display in protein β-sheets by α/β-peptides." J. Am. Chem. Soc. 2012, 134, 15906–15913. [DOI]

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28. J.K. Staples, K.M. Oshaben, W.S. Horne* "A modular synthetic platform for the construction of protein-based supramolecular polymers via coiled-coil self-assembly." Chem. Sci. 2012, 3, 3387-3392. [DOI]
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27. T.F. Cunningham, M.S. McGoff, I. Sengupta, C.P. Jaroniec, W.S. Horne*, S. Saxena* "High-resolution structure of a protein spin-label in a solvent-exposed β-sheet and comparison with DEER spectroscopy." Biochemistry 2012, 51, 6350-6359. [DOI]
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26. Z.E. Reinert, E.D. Musselman, A.H. Elcock, W.S. Horne* "A PEG-based oligomer as a backbone replacement for surface-exposed loops in a protein tertiary structure." ChemBioChem 2012, 13, 1107-1111. [DOI]
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25. W.S. Horne* "Peptide and peptoid foldamers in medicinal chemistry." Expert Opin. Drug Discovery 2011, 6, 1247-1262. [DOI]

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24. S. Wan, F. Wu, J.C. Rech, M.E. Green, R. Balachandran, W.S. Horne*, B.W. Day*, P.E. Floreancig* "Total synthesis and biological evaluation of pederin, psymberin, and highly potent analogs." J. Am. Chem. Soc. 2011, 133, 16668-16679. [DOI]
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23. C.M. Haney, M.T. Loch, W.S. Horne* "Promoting peptide α-helix formation with dynamic covalent oxime side-chain cross-links." Chem. Commun. 2011, 47, 10915-10917. [DOI]

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22. G.A. Lengyel, R.C. Frank, W.S. Horne* "Hairpin folding behavior of mixed α/β-peptides in aqueous solution." J. Am. Chem. Soc. 2011, 133, 4246–4249. [DOI]

Graduate and Postdoctoral Work
  1. L.M. Johnson, D.E. Mortenson, H.G. Yun, W.S. Horne, T.J. Ketas, M. Lu, J.P. Moore, S.H. Gellman "Enhancement of α-helix mimicry by an α/β-peptide foldamer via incorporation of a dense ionic side chain array." J. Am. Chem. Soc. 2012, 134, 7317-7320. [DOI]
  2. M.D. Boersma, H.S. Haase, K.J. Peterson-Kaufman, E.F. Lee, O.B. Clarke, P.M. Colman, B.J. Smith, W.S. Horne, W.D. Fairlie, S.H. Gellman "Evaluation of diverse α/β backbone patterns for functional α-helix mimicry: Analogues of the Bim BH3 domain." J. Am. Chem. Soc. 2012, 134, 315-323. [DOI]
  3. L.M. Johnson, W.S. Horne, S.H. Gellman "Broad distribution of energetically important contacts across an extended protein interface." J. Am. Chem. Soc. 2011, 133, 10038-10041. [DOI]
  4. E.F. Lee, B.J. Smith, W.S. Horne, K.N. Mayer, M. Evangelista, P.M. Colman, S.H. Gellman, W.D. Fairlie "Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated via sequence-based design." ChemBioChem 2011, 12, 2025-2032. [DOI]
  5. J.L. Price, W.S. Horne, S.H. Gellman "Structural consequences of β-amino acid preorganization in a self-assembling α/β-peptide: Fundamental studies of foldameric helix bundles." J. Am. Chem. Soc. 2010, 132, 12378-12387. [DOI]
  6. W.S. Horne, L.M. Johnson, T.J. Ketas, P.J. Klasse, M. Lu, J.P. Moore, S.H. Gellman "Structural and biological mimicry of protein surface recognition by α/β-peptide foldamers." Proc. Natl. Acad. Sci., U.S.A. 2009, 106, 14751-14756. [DOI]
  7. M.W. Giuliano, W.S. Horne, S.H. Gellman "An α/β-peptide helix bundle with a pure β3-amino acid core and a distinctive quaternary structure." J. Am. Chem. Soc. 2009, 131, 9860-9861. [DOI]
  8. J.M. Beierle, W.S. Horne, J.H. van Maarseveen, B. Waser, J.C. Reubi, M.R. Ghadiri "Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds for rational drug design: Receptor-selective somatostatin analogues." Angew. Chem. Int. Ed. 2009, 48, 4725-4729. [DOI]
  9. W.S. Horne, C.A. Olsen, J.M. Beierle, A. Montero, M.R. Ghadiri "Probing the bioactive conformation of an archetypal natural product HDAC inhibitor using conformationally homogeneous triazole-modified cyclic tetrapeptides." Angew. Chem. Int. Ed. 2009, 48, 4718-4724. [DOI]
  10. W.S. Horne, S.H. Gellman "Foldamers with heterogeneous backbones." Acc. Chem. Res. 2008, 41, 1399-1408. [DOI]
  11. W.S. Horne, J.L. Price, S.H. Gellman "Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly." Proc. Natl. Acad. Sci., U.S.A. 2008, 105, 9151-9156. [DOI]
  12. W.S. Horne, M.D. Boersma, M.A. Windsor, S.H. Gellman "Sequence-based design of α/β-peptide foldamers that mimic BH3 domains." Angew. Chem. Int. Ed. 2008, 47, 2853-2856. [DOI]
  13. J.L. Price, W.S. Horne, S.H. Gellman "Discrete heterogeneous quaternary structure formed by α/β-peptide foldamers and α-peptides." J. Am. Chem. Soc. 2007, 129, 6376-6377. [DOI]
  14. Y. Chi, E.P. English, W.C. Pomerantz, W.S. Horne, L.A. Joyce, L.R. Alexander, W.S Fleming, E.A. Hopkins, S.H. Gellman "Practical synthesis of enantiomerically pure β2-amino acids via proline-catalyzed diastereoselective aminomethylation of aldehydes." J. Am. Chem. Soc. 2007, 129, 6050-6055. [DOI]
  15. W.S. Horne, J.L. Price, J.L. Keck, S.H. Gellman "Helix bundle quaternary structure from α/β-peptide foldamers." J. Am. Chem. Soc. 2007, 129, 4178-4180. [DOI]
  16. N. Ashkenasy, W.S. Horne, M.R. Ghadiri "Design of self-assembling peptide nanotubes with delocalized electronic states." Small 2006, 2, 99-102. [DOI]
  17. J.H. van Maarseveen, W.S. Horne, M.R. Ghadiri "Efficient route to C2 symmetric heterocyclic backbone modified cyclic peptides." Org. Lett. 2005, 7, 4503-4506. [DOI]
  18. W.S. Horne, C.M. Wiethoff, C.L. Cui, K.M. Wilcoxen, M.A. Amorin, M.R. Ghadiri, G.N. Nemerow "Antiviral cyclic D,L-α-peptides: Targeting a general biochemical pathway in virus infections." Bioorg. Med. Chem. 2005, 13, 5145-5153. [DOI]
  19. W.S. Horne, N. Ashkenasy, M.R. Ghadiri "Modulating charge transfer through cyclic D,L-α-peptide self-assembly." Chem.-Eur. J. 2005, 11, 1137-1144. [DOI]
  20. W.S. Horne, M.K. Yadav, C.D. Stout, M.R. Ghadiri "Heterocyclic peptide backbone modifications in an α-helical coiled coil." J. Am. Chem. Soc. 2004, 126, 15366-15367. [DOI]
  21. W.S. Horne, C.D. Stout, M.R. Ghadiri "A heterocyclic peptide nanotube." J. Am. Chem. Soc. 2003, 125, 9372-9376. [DOI]

Last updated: 01/14/2025