Lee et al. Science 298, 799-804 (2002

These observations have several important implications. The control of most, if not all, cellular processes is characterized by networks of transcriptional regulators that regulate other regulators. It is also evident that the effects of transcriptional regulator mutations on global gene expression, as measured by expression profiling (1, 4, 5, 19, 38-48), are as likely to reflect the effects of the network of regulators as they are to identify the direct targets of a single regulator.