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We shall estimate the coefficient a with the help of parameters characterizing the rates of generation and death of different agents of infectious diseases, their tolerance to drags or vaccines, the rates of diseases spreading. The observation of parameters, characterizing immune, endocrine, energetic and other functional systems of organism shall help to estimate the indices, characterizing the restoration possibility of population and therefore parameter b. There are some mathematical models, that allow estimate degree of the above systemsí functions violation and their reserves. We shall estimate the coefficient c with the help of following parameters: a total population, annual population growth, percent of population urbanized, average annual growth rate, GNP per capita, GNP per capita annual growth rate, human development index, unemployment rate, total adult literacy rate, crude birth rate, crude death rate, maternal mortality, life expectancy, total fertility rate, infant mortality. The observation of parameters, characterizing impact of geographic factors, ecological situation and others shall help to estimate the coefficient d.