16(12 MechanoBiology Laboratory | University of Pittsburgh School of Medicine
Recent Refereed Publications (2016-2023) | Refereed Publications Full List | Book Chapters

Recent Refereed Publications (2016-2023)
(Click here for a full list of publications)

    1. Zhang, J.; Brown, R.; Hogan, M.V. ; Wang, JH-C. Mitigating scar tissue formation in tendon injuries: Targeting HMGB1, AMPK activation, and myofibroblast migration all at once. Pharmaceuticals, 16(12): 1739, 2023, https://doi.org/10.3390/ph16121739.

    2. Zhang, J.; Brown, R.; Hogan, M.V. ; Onishi, K.; Wang, JH-C. Metformin improves tendon degeneration by blocking translocation of HMGB1 and suppressing tendon inflammation and senescence in aging mice. J Orthop Res, 41(6): 1161-1176, 2023.

    3. Zhang, J.; Li, F.; Augi, T.; Williamson, K.M.; Onishi, K.; Hogan, M.V. Neal, M.D. Wang, JH-C. Platelet HMGB1 in platetlet-rich plasma (PRP) promotes tendon wound healing. PLoS ONE, 16(9), 2021, https://doi.org/10.1371/journal.pone.0251166.

    4. Nie, D.; Zhou, Y.; Wang, W.; Zhang, J.; Wang, JH-C. Mechanical overloading-induced activation of mTOR signaling in tendon stem/progenitor cells contributes to tendinopathy development. Front. Cell and Develop. Biol., 2021.https://doi.org/10.3389/fcell.2021.687856.

    5. Nie, D.; Zhang, J.; Zhou, Y.; Sun, J.; Wang, W.; Wang, JH-C. Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy. Stem Cell Intl, 2021, Article ID 6638249 https://doi.org/10.1155/2021/6638249.

    6. Zhang, J.; Li, F.; Williamson, K.M.; Tan, S.; Scott, D.; Onishi, K.; Hogan, M.V.; Wang, JH-C. Characterization of the structure, vascularity, and stem/progenitor cell populations in porcine Achilles tendon. Cell and Tissue Res, 2021 Jan 26.doi: 10.1007/s00441-020-03379-3.

    7. Zhang, J.; Nie, D.; Williamson, K.; McDowell, A.; Hogan, M.V.; Wang, JH-C. Moderate and intensive mechanical loading differentially modulate the phenotype of tendon stem/progenitor cells in vivo. PLoS ONE, Dec 29;15(12):e0242640. doi: 10.1371/journal.pone.0242640. eCollection 2020.

    8. Zhang, J.; Li, F.; Nie, D; Onishi, K.; Hogan, M.V.; Wang, JH-C. Effect of metformin on development of tendinopathy due to mechanical overloading in an animal model. Foot and Ankle Int, 41 (12): 1455-1465, 2020. (2020 J. Leonard Goldner Award Winner).

    9. Hogan, M.V.; Scott, D.M.; Canton, S.P.; LaBaze, D.; Yan, A.Y.; Wang, JH-C. Biologic therapies for foot and ankle injuries. Expert Opin Biol Therap, 2020 Dec 31;1-14. doi: 10.1080/14712598.2021.1866534.

    10. Neph, A.; Schroeder, A.; Enseki, K.R.; Everts, P.A.; Wang, JH-C; Onishi, K. Role of Mechanical Loading for Platelet-Rich Plasma Treated Tendinopathy. Current Sports Med Rep. 2020 Jun;19(6):209-216. doi: 10.1249/JSR.0000000000000719.

    11. Yazdani, H.O.; Kaltenmeier, C.; Morder, K.; Moon, J.; Traczek, M.; Loughran, P.; Zamora, R.; Vodovotz, Y.; Li, F.; Wang, JH-C.; Geller, D.A.; Simmons, R.L.; Tohme, S. Exercise training decreases hepatic injury via changes in immune response to liver ischemia/reperfusion in mice. Hepatology, Sep 14.doi: 10.1002/hep.31552, 2020.

    12. Ferrer, GA.; Miller, RM.; Yoshida, M.; Wang, JH-C.; Musahl,V.; Debski, R. Correlation of quantitative ultrasound measures and supraspinatus tendon quality: a pilot study. J Med Ultrasound, 28 (3): 162-168, 2020.

    13. Ferrer, GA.; Miller, RM.; Yoshida, M.; Wang, JH-C.; Musahl, V.; Debski,R. Localized rotator cuff degeneration for cadaveric shoulders with and without tears isolated to the supraspinatus tendon.Clin Anat, 2019, https://doi.org/10.1002/ca.23526.

    14. Zhao, G.; Zhang, J.; Nie, D.; Zhou, Y.; Li, F.; Onishi, K.; Billiar,T.; Wang, JH-C. HMGB1 mediates the development of tendinopathy due to mechanical overloading. PLoS ONE 14(9):e2222369, 2019.

    15. Wu, H.; Wang, JH-C.; Wang, QM.; Wang, JH-C. A study of Love wave acoustic biosensors monitoring the adhesion process of tendon stem cells (TSCs). Eur Biophys J, https://doi.org/10.1007/s00249-019-01349-4, 2019.

    16. Zhang, ZX.; Zhu, J.; Zhou, Y.; Thampatty, BP.; Wang, JH-C. Tendon stem/progenitor cells and their interactions with extracellular matrix and mechanical loading. Stem cell International, Oct 13, eCollection https://doi.org/10.1155/2019/3674647, 2019.

    17. Milano, G.; Sánchez, M.; Jo, CH.; Saccomanno, MF., Thampatty, BP.; Wang, JH-C. Platelet-rich plasma in orthopaedic sports medicine: state of the art. JISAKOS, 4(4):1–8, 2019.

    18. Neph, A.; Onishi, K.; Rocha, JL.; Wang, JH-C. Myths and facts of in-office regenerative procedures for tendinopathy: literature review. American Journal of Physical Medicine and Rehabilitation, Jun;98(6):500-511, 2019.

    19. Zhang, J.; Nie, D.; Rocha, JL.; Hogan, MV.; Wang, JH-C. Selectively activated PRP exerts differential effects on tendon stem/progenitor cells and tendon healing. Journal of Tissue Engineering, Jan-Dec; 10: 2041731418820034, 2019.

    20. Chen, B.; Zhang, J.; Nie, D.; Zhao, G.; Fu, F.; Wang, JH-C. Characterization of the structure of rabbit ACL and its stem/progenitor cells. Journal of Cellular Biochemistry, 120: 7446-7457, 2019.

    21. Zhang, J.; Nie, D.; Rocha, JL; Hogan, MV.; Wang, JH-C. Characterization of the structure, cells, and cellular mechanobiological response of human plantar fascia. Journal of Tissue Engineering, 9:1-16, 2018.

    22. Washburn, N.; Onishi, K.; and Wang, JH-C. "Ultrasound elastography and ultrasound tissue characterization for tendon evaluation." Journal of Orthopaedic Translation, 15:1-12,2018.

    23. Zhang, J., Wang, JH-C. "Maintenance of tendon stem/progenitor cells in culture." Methods in Molecular Biology, Vol 1842, Eds. Shree Ram Singh and Pranela Rameshwar, 2018.

    24. Wang, JH-C.; Thampatty, B.P. : "Advances in tendon mechanobiology." Mechanobiology in Health and Disease (1st edition), ed. Stefaan Verbruggen, Academic Press, 2018.

    25. Zhou, Y.; Zhang, Y.; Yang, J.; Narava, M.; Zhao, G.; Yuan, T.; Wu, H.; Zheng, N.; Hogan, M.V.; Wang, JH-C. "Kartogenin with PRP promotes the formation of fibrocartilage zone in the tendon-bone interface." Journal of Tissue Eng and Regenerative Medicine, 2017. doi: 10.1002/term.2258.

    26. Bhavani, P.T.; Wang, JH-C. "Mechanobiology of Young and Aging Tendons: In Vivo Studies with Treadmill Running." Journal of Orthopaedic Research 2017, doi: 10.1002/jor.23761.

    27. Jia, H.; Ma, X.; Wei, Y.; Tong, W.; Tower, R. ; Chandra, A.; Wang, L.; Sun, Z.; Yang, Z.; Badar, F.; Zhang, K.; Tseng, W.; Kramer, I.; Kneissel, M.; Xia, Y.; Liu, X.; Wang, JH-C.; Han, L.; Enomoto-Iwamoto1, M.; Qin, L. "Subchondral bone plate sclerosis during late osteoarthritis is caused by loading-induced reduction in Sclerostin." Arthritis & Rheumatology. doi: 10.1002/art.40351

    28. Zhang, J.; Yuan, T.; Zheng, N.; Zhou, Y.; Hogan, M.V.; Wang, JH-C. "The combined use of Kartogenin (KGN) and PRP promotes fibrocartilage formation in Wounded Rat Achilles Tendon Entheses." Bone Joint Res. 6(4):231-244, 2017.

    29. Wu, H.; Xiong, X.; Zu, H.; Wang, JH-C.; Wang, Q.-M. "Theoretical analysis of Love wave biosensors in liquid with a viscoelastic wave guiding layer" Journal of Applied Physics, 121: 054501, 2017.

    30. Yiqin Zhou; Jianying Zhang; Jinsong Yang; Manoj Narava; Guangyi Zhao; Ting Yuan; Haishan Wu; Nigel Zheng; MaCalus V. Hogan and Wang, JH-C. "Kartogenin with PRP promotes the formation of fibrocartilage zone in the tendon-bone interface" J Tissue Eng Regen Med 2017. DOI: 10.1002/term.2258. Epub 2017 Jan 27

    31. Zhou, Y.; *Wang, JH-C. PRP treatment efficacy for tendinopathy: a review of basic science studies. BioMed Res Int, 2016:9103792. doi: 10.1115/2016/9103792.

    32. Li, Z-M.; *Wang, JH-C.; Woo, SL-Y. Biomechanics and Mechanobiology of Ligaments and Tendons, Journal of Medical Biomechanics, 31:301-307, 2016.

    33. *Wang, JH-C.; Nirmala, X. Perspectives on Improving the Efficacy of PRP Treatment for Tendinopathy, Journal of Musculoskeletal Disorders and Treatment, 2:015, 2016.

    34. Wang, JH-C.; Nirmala, X. Application of TSCs and PRP to treat tendon injuries. Oper Tech Orthop, 26 (2): 68-72, 2016.

    35. Wang, JH-C.; Komatsu, I. "Tendon Stem Cells: Mechanobiology and Development of Tendinopathy." Cytoskeleton Adv Exp Med Biol, Vol. 920, Paul Ackermann and David A. Hart (Eds): Metabolic Influences on Risk for Tendon Disorders, 2016.

    36. Hossain, M; Zhao, G; Woo, M; Wang; Wang, JH-C. ;Jian-Ping. "Deletion of calponin 2 in mouse fibroblasts increases myosin II-dependent cell traction force." Biochemistry 2016. 2016 Nov 1;55(43):6046-6055

    37. Wu, H.; Zhao, G.; Zu, H.; Wang, JH-C.; Wang, Q.M. Real-time monitoring of platelet activation using quartz thickness shear mode (TSM) resonator sensors. Biophysical J., 110: 669-679, 2016. [Pubmed]

    38. Yuan, T.; Zhang, J.; Zhao, G.; Zhou, Y.; Zhang, C.Q.; Wang, JH-C. Creating an animal model of tendinopathy by inducing chondrogenic differentiation with kartogenin. PloS ONE, 11(2):e0148557, 2016. [Pubmed]

    39. Zhang, J.; Yuan, T.; Wang, JH-C. Moderate treadmill running exercise prior to tendon injury enhances wound healing aging rats. Ontotarget, 2016 Feb 23;7(8):8498-512 [Pubmed]