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Here�s how
Agrobacterium causes the formation of galls. This clever bacterium carries
around plant genes that it doesn�t use, but when it detects an opening --
meaning a wounded plant cell (shown by the breaks in the wall around the
cell), it attaches and slips those genes, themselves on a separate small
plasmid called the Ti plasmid, into the plant. These genes find their way
into the cells nucleus and are inserted into its DNA within its
chromosomes. The bacterial genes reprogram the plant a bit, first to grow a
tumor and second to make special compounds that the bacteria in the
vicinity can use for nourishment. The tumor doesn�t kill the plant, it just
coaxes it to make food for the bacterium. What Schell and others did was
remove the gall-forming genes, incorporate a new gene, putting Agrobacterium
to work as a gene-delivery system in order to improve crop plants. The
tumor-forming genes were replaced with genes that are beneficial for the
plants, such as a gene that codes for a protein that is toxic to insects
that feed on a plant.
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