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Kidney as target organ in COVID-19
•Mechanism
of kidney involvement not clear
•Multiorgan
failure and shock
•Cytokine
storm
•Direct
infection – tubular cells
•COVID
19 binds to ACE2 receptor to enter cells
•ACE2
abundant in podocytes and proximal tubular epithelial cells
per single-cell RNAseq data reported by
Xu et al (Preprint 2020)
•Report
from Wuhan 23/85 patients AKI (Human
Kidney is a Target for Novel Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-Infection. Bo Diao, et
al medRxiv 2020.03.04.20031120; doi: https://doi.org/10.1101/2020.03.04.20031120)
•Kidney
tissues postmortem(n=6) severe ATN and lymphocyte
infiltration. Immunohistochemistry showed that SARS-CoV-2 NP
antigen accumulated in kidney tubules. Viral infection not
only induces CD68+ macrophages infiltrated into
tubulointerstitium, but also enhances
complement C5b-9 deposition on tubules.
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