Search for most updated materials ↑

 

front |1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |review

Kidney as target organ in COVID-19 •Mechanism of kidney involvement not clear •Multiorgan failure and shock •Cytokine storm •Direct infection – tubular cells •COVID 19 binds to ACE2 receptor to enter cells •ACE2 abundant in podocytes and proximal tubular epithelial cells per single-cell RNAseq data reported by Xu et al (Preprint 2020) •Report from Wuhan 23/85 patients AKI (Human Kidney is a Target for Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-Infection. Bo Diao, et al medRxiv 2020.03.04.20031120; doi: https://doi.org/10.1101/2020.03.04.20031120) •Kidney tissues postmortem(n=6) severe ATN and lymphocyte infiltration. Immunohistochemistry showed that SARS-CoV-2 NP antigen accumulated in kidney tubules. Viral infection not only induces CD68+ macrophages infiltrated into tubulointerstitium, but also enhances complement C5b-9 deposition on tubules.