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As occurs in all studies of causality, evaluative research studies must be based on a plausible causality model to establish the experimental hypothesis.

In this case, the hypothesis was established after observing considerable variations in the frequency of prescription of the different non-steroid anti-inflammatory drugs: 7 times in the case of piroxicam, 18 times in the case of tenoxicam and up to 22 times in the case of diclofenac.