To understand current complexity in medicine we go back in time (image borrowed from: http://worldalldetails.com/article_image/costa_rica_america_134592.jpg) and reflect on how some humans became the first animal species to provide other humans with interventions that had healing properties? Just imagine yourself airdropped into this past with lush green forests hoarding some of the blockbuster molecules of the future? Just imagine how humans would have noticed some of their fellow humans becoming horribly ill and even dying after consuming some of these plants or fruits and then one day some one among them may have consumed a smaller fraction of it in an attempt to commit suicide while in extreme pain when s/he would have become aware of the astounding healing properties of that particular herb. And so began the saga of medicine when some humans were driven by a natural instinct to try out different combinations of herbs that they found stimulating or relaxing or pain relieving and some of them even had the capacity to store the information of a myriad different herbs in their brains as to their effect size in relation to other herbs (that seemingly never had much effect). Most of these humans were putting their tasted herbs on a test/trial by using themselves as a single un-blinded subject, selecting one over the other with complete bias and faith on whatever knowledge and expertise they gained in the above manner. They had a tremendous amount of faith in the efficacy of their own herbs and a lot of those who savoured these as beneficiaries also developed a tremendous amount of faith in them. Faith based medicine FBM survives to this very day in various identifiable and unidentifiable flavours.