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1.A
primary concern in conducting a meta-analysis is “publication bias”,
meaning that published papers may be slanted (biased) towards those that
show statistically significant findings.
2.This
can give the appearance of a treatment or intervention be more effective
than it is in reality.
3.(1)
Dickersin K, Chan S, Chalmers TC, et al. Publication bias and clinical
trials. Controlled Clin Trials 1987; 8: 343-53
4.(2)
EEasterbrook PJ, Berlin JA, Gopalan R, Matthews DR. Publication bias in
clinical research. Lancet 1991;337:86772
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