1.This is an example of meta-analyses comparing low (standard) dose or statin therapy versus high-dose with respect to a range of cardiovascular disease outcomes.

2.Whereas the results are highly statistically significant, the absolute difference in major vascular event rates (22.1% versus 19.0%) is rather modest.

3.Cholesterol Treatment Trialists' (CTT) Collaboration. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials. Lancet. 2010 November 13; 376(9753): 1670–1681.