Gleevec®—Important Considerations1

• Use of Gleevec is contraindicated in patients with hypersensitivity to imatinib or to any other

component of Gleevec.

• Women of childbearing potential should be advised to avoid becoming pregnant.

• Gleevec is often associated with edema and occasionally serious fluid retention*; GI irritation

(and should be taken with food and a large glass of water to minimize this problem); anemia,

neutropenia, thrombocytopenia, or occasionally severe hepatotoxicity

or hemorrhage.

• Gleevec is metabolized by the CYP3A4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6, and

CYP2C9.

• Please refer to slides 18 and 19 for most common adverse events and full Prescribing

Information for more detailed safety information and potential drug interactions.

*Patients should be weighed and monitored regularly for signs and symptoms of edema, which can be serious or life threatening.