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Hepatitis virus E is a 27~34 nm RNA virus. It is enterally transmitted non-A, non-B hepatitis, and outbreaks occur primarily as water-borne epidemics in countries with poor environmental sanitation. The victims are mostly in young adults (15 - 40 yrs), and uncommon in children and elderlies.

In pregnant women, the symptoms are severe with case fatality rate of as high as 20 %. It is a self-limiting infection like as HAV without chronicity.