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Taiwan was a high-prevalent endemic area of HAV infection with 95 % of population having been infected with HAV under the age of 15 years before the year 1981. In 1989, the infection rate of the age group of 15 years dropped to 33 % and that of 13 years to 15 % in western plain region of Taiwan, however, that of mountain region in eastern and central Taiwan remained as high as in 1981 with 85 ~ 90 % infection rate in age group of 7 ~ 14 years. During those 8 years after 1981, the environmental sanitation in western plain region of Taiwan had showed remarkable improvement, while the eastern mountain region had remained in the same poor condition. It has been proven that good environmental sanitation and individual hygienic habit would improve and eradicate the infection of HAV.