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Transmission of HCV --- HCV is a blood-borne virus circulating in low titer in the blood stream. Most possible causes for transmission of HCV are transfusion of blood or blood products, transplantation of organs, and sharing of contaminated needles. In less than 50 % of acute hepatitis C patients, the history of exposure can be identified. A small number of studies demonstrate perinatal, sexual, household, and occupational transmission. The degree of the risk of transmission depends on the types and size, as well as the titer of virus, of inoculum and the route of transmission.